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An interesting study observed that lifelong aerobic-trained individuals (with 40 ml⋅kg –1 ⋅min –1 VO 2 max) had higher blood Tregs markers concentrations (IL-10, forkhead box P3, and transforming growth factor-β), low ↓TNF-α/IL-10↑ ratio associated with lower memory CD8 + T cells when compared to sedentary counterparts (with 29 ml⋅kg –1 ⋅min –1 VO 2 max) (Minuzzi et al., 2017, 2018)

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30 Further work is being carried out to investigate these findings